On February 24, 2022, the U.S. Food and Drug Administration (FDA) revised the emergency use authorization for tixagevimab co-packaged with cilgavimab (EVUSHELD™) to change the initial dose for the authorized use as pre-exposure prophylaxis of COVID-19 in certain adults and pediatric patients.

The Centers for Medicare & Medicaid Services (CMS) has released a Medicare payment code (Q0221) effective February 24, 2022 for administering the combination monoclonal antibody therapy Evusheld to prevent COVID-19 in certain patients.

  • Long Descriptor: Injection, tixagevimab and cilgavimab, for the pre-exposure prophylaxis only, for certain adults and pediatric individuals (12 years of age and older weighing at least 40kg) with no known sars-cov-2 exposure, who either have moderate to severely compromised immune systems or for whom vaccination with any available covid-19 vaccine is not recommended due to a history of severe adverse reaction to a covid-19 vaccine(s) and/or covid-19 vaccine component(s), 600 mg
  • Short Descriptor: Tixagev and cilgav, 600mg

Use the existing administration codes — M0220 and M0221.

Source: U.S. Centers for Medicare & Medicaid Services (CMS)

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